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- Title
Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation.
- Authors
Karlis, George; Iacovidou, Nicoletta; Lelovas, Pavlos; Niforopoulou, Panagiota; Papalois, Apostolos; Siafaka, Ioanna; Mentzelopoulos, Spyros; Xanthos, Theodoros
- Abstract
Purpose: The purpose of the experiment was to compare the effects of nifekalant and amiodarone on the return of spontaneous circulation (ROSC), survival, as well as on the hemodynamic parameters in a swine model of prolonged ventricular fibrillation (VF). Methods: After 8 min of untreated VF, bolus doses of epinephrine (adrenaline) and either nifekalant, or amiodarone, or saline ( n = 10 per group), were administered after randomization. Cardiopulmonary resuscitation (CPR) was commenced immediately after drug administration and defibrillation was attempted 2 min later. CPR was resumed for another 2 min after each defibrillation attempt and the same dose of adrenaline was given every 4th minute during CPR. Results: Forty-eight hour survival was significantly higher with nifekalant compared to amiodarone ( p < 0.001) and saline ( p = 0.02), (9/10 vs. 0/10 vs. 3/10, respectively). Systolic aortic pressure, diastolic aortic pressure and coronary perfusion pressure were significantly higher with nifekalant during CPR and immediate post-resuscitation period ( p < 0.05). The animals in the amiodarone group had a slower heart rate at the 1st and 45th min post-ROSC ( p < 0.001 and p = 0.006, respectively). The number of electric shocks required for terminating VF, time to ROSC and adrenaline dose were significantly higher with amiodarone compared to nifekalant ( p < 0.001). Conclusions: Nifekalant showed a more favorable hemodynamic profile and improved survival compared to amiodarone and saline in this swine model.
- Subjects
AMIODARONE; CARDIOPULMONARY resuscitation; DRUG administration; ADRENALINE; HEART beat
- Publication
Cardiovascular Drugs & Therapy, 2015, Vol 29, Issue 5, p425
- ISSN
0920-3206
- Publication type
Article
- DOI
10.1007/s10557-015-6604-7