We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Paediatric lung transplantation: the impact of age on the survival.
- Authors
Otani, Shinji; Yamamoto, Haruchika; Tanaka, Shin; Tomioka, Yasuaki; Matsubara, Kei; Shimizu, Dai; Shiotani, Toshio; Suzawa, Ken; Miyoshi, Kentaroh; Yamamoto, Hiromasa; Okazaki, Mikio; Sugimoto, Seiichiro; Yamane, Masaomi; Toyooka, Shinichi
- Abstract
Objectives: We herein review the outcomes of paediatric lung transplantation (LTx) and analyse subgroups divided by age. Methods: We retrospectively reviewed 43 consecutive paediatric LTx recipients (< 18 years old: cadaveric LTx [n = 9], living-donor lobar LTx [n = 34]). We also analysed subgroups of patients 1–6 years old (n = 10) and 7–17 years old (n = 33). Results: The 1-, 5- and 10-year overall survival (OS) rates in paediatric recipients were 93%, 82% and 67%, respectively. The 1-, 5- and 10-year graft dysfunction (GD)-free survival rates in paediatric recipients were 85%, 59% and 31%, respectively. The 1- and 5-year OS in the 1- to 6-year-old vs. 7- to 17-year-old groups were 70% vs. 100% and 48% vs. 93%, respectively (p < 0.0001). The 1- and 5-year GD-free survival rates in the 1- to 6-year-old vs. 7- to 17-year-old groups were 60% vs. 93% and 24% vs. 69%, respectively (p = 0.024). The 1- to 6-year-old group showed higher rates of non-standard LTx (p = 0.0001), interstitial pneumonia (p = 0.004) and ventilator dependency (p = 0.007) than the 7- to 17-year-old group. Conclusion: Paediatric recipients under 7 years old seemed to have a higher risk of mortality and GD than those 7 years old and older.
- Subjects
LUNG transplantation; PEDIATRICS; PULMONARY fibrosis; SURVIVAL rate; OVERALL survival
- Publication
Surgery Today, 2022, Vol 52, Issue 11, p1540
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-022-02492-w