We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nitroreductase‐Responsive Photosensitizers for Selective Imaging and Photo‐Inactivation of Intracellular Bacteria.
- Authors
Zhou, Wanpeng; Da, Xuwen; Jian, Yao; Peng, Yatong; Liu, Xiulian; Xu, Yunli; Wu, Yao; Wang, Xuesong; Zhou, Qianxiong
- Abstract
Intracellular Staphylococcus aureus (S. aureus), especially the methicillin resistant staphylococcus aureus (MRSA), are difficult to detect and eradicate due to the protection by the host cells. Antibacterial photodynamic therapy (aPDT) offers promise in treating intracellular bacteria, provided that selective damage to the bacteria ranther than host cells can be realized. According to the different nitroreductase (NTR) levels in mammalian cells and S. aureus, herein NTR‐responsive photosensitizers (PSs) (T)CyI−NO2 were designed and synthesized. The emission and 1O2 generation of (T)CyI−NO2 are quenched by the 4‐nitrobenzyl group, but can be specifically switched on by bacterial NTR. Therefore, selective imaging and photo‐inactivation of intracellular S. aureus and MRSA were achieved. Our findings may pave the way for the development of more efficient and selective aPDT agents to combat intractable intracellular infections.
- Subjects
METHICILLIN-resistant staphylococcus aureus; PHOTOSENSITIZERS; PHOTODYNAMIC therapy; BACTERIA; STAPHYLOCOCCUS aureus
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 16, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202303766