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- Title
Long‐Acting Insulin‐Zwitterionic Polymer Conjugate Mitigates Hypoglycemia.
- Authors
Zeng, Zhipeng; Hou, Wangmeng; Hu, Zhitao; Liu, Lixin; Liu, Zhijia; Shi, Yi; Li, Mingqiang; Chen, Yongming
- Abstract
Insulin, a main medication to control glycemia of type 1 and advanced type 2 diabetes, faces problems of a short half‐life and poor stability during its clinical use. Zwitterionic polymer shows unique properties of antifouling and low immunogenicity. Here, we have synthesized a new insulin‐zwitterionic polymer conjugate (INS‐PMPC) through grafting‐from strategy by controlled radical polymerization. Apart from showing excellent stability upon mechanical agitation, the resulting INS‐PMPC conjugate provided over 20 h of glycemic control due to improved pharmacokinetics in diabetic mice with one single subcutaneous injection. Most importantly, this insulin‐zwitterionic polymer conjugate significantly decreases the incidence of hypoglycemia.
- Subjects
HYPERGLYCEMIA; HYPOGLYCEMIA; POLYZWITTERIONS; POLYMERS; GLYCEMIC control; TYPE 2 diabetes; INSULIN derivatives; INSULIN
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 12, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202203460