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- Title
Bimetallic Ruthenium Nitrosyl Complexes with Enhanced Two‐Photon Absorption Properties for Nitric Oxide Delivery.
- Authors
Juarez‐Martinez, Yael; Labra‐Vázquez, Pablo; Enríquez‐Cabrera, Alejandro; Leon‐Rojas, Andrés F.; Martínez‐Bourget, Diego; Lacroix, Pascal G.; Tassé, Marine; Mallet‐Ladeira, Sonia; Farfán, Norberto; Santillan, Rosa; Ramos‐Ortiz, Gabriel; Malval, Jean‐Pierre; Malfant, Isabelle
- Abstract
One monometallic and three bimetallic ruthenium nitrosyl (RuNO) complexes are presented and fully characterized in reference to a parent monometallic complex of formula [FTRu(bpy)(NO)]3+, where FT is a fluorenyl‐substituted terpyridine ligand, and bpy the 2,2'‐bipyridine. These new complexes are built with the new ligands FFT, TFT, TFFT, and TF‐CC‐TF (where an alkyne C≡C group is inserted between two fluorenes). The crystal structures of the bis‐RuNO2 and bis‐RuNO complexes built from the TFT ligand are presented. The evolution of the spectroscopic features (intensities and energies) along the series, at one‐photon absorption (OPA) correlates well with the TD‐DFT computations. A spectacular effect is observed at two‐photon absorption (TPA) with a large enhancement of the molecular cross‐section (σTPA), in the bimetallic species. In the best case, σTPA is equal to 1523±98 GM at 700 nm, in the therapeutic window of transparency of biological tissues. All compounds are capable of releasing NO⋅ under irradiation, which leads to promising applications in TPA‐based drug delivery.
- Subjects
RUTHENIUM compounds; NITRIC oxide; NITROSYL compounds; ABSORPTION; INDIUM gallium zinc oxide; TISSUES; RUTHENIUM
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 62, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202201692