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- Title
Fundus autofluorescence abnormalities can predict fluorescein angiography abnormalities in patients with chronic central serous chorioretinopathy.
- Authors
Mohabati, Danial; Boon, Camiel J. F.; Hoyng, Carel B.; Purtskhvanidze, Konstantine; Roider, Johann; van Dijk, Elon H. C.
- Abstract
Purpose: This study is to assess the possible correlation between findings on fundus autofluorescence (FAF) and fluorescein angiography (FA) in patients with chronic central serous chorioretinopathy (cCSC). Methods: This multicentre retrospective cohort study included 71 cCSC patients (92 eyes) with at least 6 months of follow-up, who had a FAF-FA imaging discrepancy larger than 0.5 optic disc diameters in size in the corresponding areas of hyperfluorescent abnormalities. A comparison was performed between progression in size of areas of hyperautofluorescent retinal pigment epithelium (RPE) abnormalities on FAF (HF-FAF) and the hyperfluorescent areas on FA (HF-FA) at first visit and last visit. The possible correlations were estimated between FAF-FA discrepancy and disease characteristics. Results: The median area of HF-FAF at first visit was 7.48 mm2 (1.41–27.9). The median area of HF-FA at first visit and last visit was 2.40 mm2 (0.02–17.27) and 5.22 mm2 (0.53–25.62), respectively. FAF-FA discrepancy was associated with follow-up duration and the area of HF-FAF at first visit. A mathematical algorithm for grading FAF-FA discrepancy in time was suggested, which predicted the enlargement of hyperfluorescent RPE abnormalities on FA in 82.6% of cases. Conclusion: There is a statistically significant relationship between the areas of HF-FAF and HF-FA in cCSC patients with FAF-FA imaging discrepancy at first presentation. Long-term changes in RPE alterations in cCSC on FA can be predicted based on baseline HF-FAF and follow-up duration.
- Subjects
FLUORESCENCE angiography; BIOFLUORESCENCE; RHODOPSIN; OPTIC disc; HUMAN abnormalities
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2023, Vol 261, Issue 9, p2489
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-023-06042-z