We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In ovariectomy-induced osteoporotic rat models, BMP-2 substantially reversed an impaired alveolar bone regeneration whereas PDGF-BB failed.
- Authors
Kim, Hyun Ju; Kim, Kyoung-Hwa; Lee, Yong-Moo; Ku, Young; Rhyu, In-Chul; Seol, Yang-Jo
- Abstract
Objectives: We previously suggested an ovariectomy (OVX)-induced osteoporotic rat model showing an impaired alveolar bone defect healing. This study aimed to evaluate and compare the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) on alveolar bone defect healing in OVX-induced osteoporotic rats. Materials and Methods: A total of forty-one female rats were divided into four groups: a collagen group (n=10), a PDGF-BB group (n=11), a BMP-2 group (n=10), and a control group (n=10). Four months after OVX, alveolar bone drill-hole defects were created and grafted with collagen gel, rhPDGF-BB/collagen gel, or rhBMP-2/collagen gel. The defects in the control group were not grafted with any material. Defect healing was evaluated by histological, histomorphometric, and microcomputed tomographic (micro-CT) analyses at 2 and 4 weeks. Results: According to the micro-CT analysis, the BMP-2 group exhibited the greatest bone volume fraction among all groups, while the PDGF-BB group did not show significant differences compared with the collagen group. The histomorphometric analysis showed a significantly larger amount of new bone area in the BMP-2 group than in the control and collagen groups at 4 weeks; however, the PDGF-BB group did not reach significant superiority compared with the other groups. Conclusions: Alveolar bone regeneration was significantly enhanced by the local use of rhBMP-2/collagen gel compared with the use of rhPDGF-BB/collagen gel in OVX-induced osteoporotic rats. Clinical Relevance: A treatment modality using rhBMP-2 may be a promising approach to promote alveolar bone regeneration in patients suffering from postmenopausal osteoporosis.
- Subjects
ALVEOLAR process; BONE regeneration; ANIMAL disease models; OSTEOPOROSIS; OSTEOPOROSIS in women; COMPACT bone; BLOOD platelets
- Publication
Clinical Oral Investigations, 2021, Vol 25, Issue 11, p6159
- ISSN
1432-6981
- Publication type
Article
- DOI
10.1007/s00784-021-03915-7