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- Title
Bambuterol: Clinical Effects of Different Doses of a Long-Acting Bronchodilator Prodrug.
- Authors
Sandström, T.; Åsander, L.; Clemmensen, I.H.; Eklund, G.; Gnosspelius, Y.; Klarlund Pedersen, B.; Persson, G.; Ravn, S.; Rosenhall, L.; Weeke, B.
- Abstract
Sixty-eight asthmatics participated in a dose-finding study on bambuterol, a terbutaline prodrug, administered once every evening. Bambuterol administrations of 0.185, 0.270 and 0.400 mg/kg gave effective and long-lasting bronchodilation, for at least 24 h, with the two higher doses probably close to the maximal effect of the drug. Bambuterol 0.400 mg/kg was associated with more adverse effects than bambuterol 0.185 mg/kg. The side effects were those expected in oral β2-agonist treatment and mainly experienced by patients who had not been on oral β2-agonists before. The most favourable of the investigated doses was found to be 0.270 mg/kg. It can not be excluded, however, that a somewhat lower dose may still be as beneficial. This will be investigated in forthcoming studies. Copyright © 1988 S. Karger AG, Basel
- Publication
Respiration, 1988, Vol 53, Issue 1, p31
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000195393