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- Title
Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III.
- Authors
Rosen, Craig A.; Sodroski, Joseph G.; Goh, Wei Chun; Dayton, Andrew I.; Lippke, Judith; Haseltine, William A.
- Abstract
The level of synthesis of viral proteins and heterologous proteins under the control of long terminal repeat sequences of human T-lymphotropic virus type HI (HTLV-III or LAV) increases dramatically in cells that constitutively express the HTLV-III trans-activator protein. Increased levels of protein synthesis occur without a comparable increase in the levels of corresponding messenger RNA. We propose that post-transcriptional events mediated by the HTLV-III trans-activator protein account for positive regulation of HTLV-III gene products in infected cells.
- Publication
Nature, 1986, Vol 319, Issue 6054, p555
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/319555a0