We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improved pharmacokinetic and pharmacodynamic attributes of artemether-lumefantrine-loaded solid SMEDDS for oral administration.
- Authors
Bhandari, Sameer; Bhandari, Vikram; Sood, Jatin; Jaswal, Sunil; Rana, Vikas; Bedi, Neena; Sehgal, Rakesh; Tiwary, Ashok K.
- Abstract
Objectives To evaluate the in-vivo efficacy of solid SMEDDS containing combination of artemether and lumefantrine. Methods Formulation development of solid SMEDDS containing combination of artemether and lumefantrine was carried out using spray drying technique. These S- SMEDDS were evaluated for reduction in parasitemia and mortality as well as subacute toxicity in mice. Haematology, biochemical parameters and histopathology were performed for evaluating safety of formulation. Pharmacokinetic characterization of both drugs was performed after oral administration in rats. Key findings Optimized solid SMEDDS containing low, medium and high dose were more effective in reducing parasitemia and mortality of mice as compared to marketed tablets containing high dose of these drugs. Single oral administration of solid SMEDDS containing high-dose combination could maintain plasma concentration of lumefantrine above the minimum effective concentration for ≈4 days. Conclusions Solid SMEDDS containing low-, medium- and high-dose combination of artemether and lumefantrine are more effective than marketed tablets.
- Subjects
PHARMACOKINETICS; PHARMACODYNAMICS; HISTOPATHOLOGY; BLOOD plasma; DRUG tablets
- Publication
Journal of Pharmacy & Pharmacology, 2017, Vol 69, Issue 11, p1437
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12795