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- Title
Tea tree oil (5%) body wash versus standard care (Johnson's Baby Softwash) to prevent colonization with methicillin-resistant Staphylococcus aureus in critically ill adults: a randomized controlled trial.
- Authors
Blackwood, Bronagh; Thompson, Gillian; McMullan, Ronan; Stevenson, Michael; Riley, Thomas V.; Alderdice, Fiona A.; Trinder, T. John; Lavery, Gavin G.; McAuley, Danny F.
- Abstract
Objectives To determine whether the daily use of 5% tea tree oil (TTO) body wash (Novabac 5% Skin Wash) compared with standard care [Johnson's Baby Softwash (JBS)] had a lower incidence of methicillin-resistant Staphylococcus aureus (MRSA) colonization. Patients The study setting was two intensive care units (ICUs; mixed medical, surgical and trauma) in Northern Ireland between October 2007 and July 2009. The study population comprised 391 patients who were randomized to JBS or TTO body wash. Methods This was a Phase 2/3, prospective, open-label, randomized, controlled trial. Trial registration: ISRCTN65190967. The primary outcome was new MRSA colonization during ICU stay. Secondary outcomes included the incidence of MRSA bacteraemia and maximum increase in sequential organ failure assessment score. Results A total of 445 patients were randomized to the study. After randomization, 54 patients were withdrawn; 30 because of a positive MRSA screen at study entry, 11 due to lack of consent, 11 were inappropriately randomized and 2 had adverse reactions. Thirty-nine (10%) patients developed new MRSA colonization (JBS n = 22, 11.2%; TTO body wash n = 17, 8.7%). The difference in percentage colonized (2.5%, 95% CI − 8.95 to 3.94; P = 0.50) was not significant. The mean maximum increase in sequential organ failure assessment score was not significant (JBS 1.44, SD 1.92; TTO body wash 1.28, SD 1.79; P = 0.85) and no study patients developed MRSA bacteraemia. Conclusions Compared with JBS, TTO body wash cannot be recommended as an effective means of reducing MRSA colonization.
- Subjects
TEA tree oil; ANTISEPTICS; JOHNSON &; Johnson (Company); METHICILLIN-resistant staphylococcus aureus; STAPHYLOCOCCUS aureus
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2013, Vol 68, Issue 5, p1193
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dks501