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- Title
iSwathX: an interactive web-based application for extension of DIA peptide reference libraries.
- Authors
Noor, Zainab; Mohamedali, Abidali; Ranganathan, Shoba; Wu, Jemma X; Pascovici, Dana; Molloy, Mark P; Baker, Mark S
- Abstract
Summary Large-scale peptide mass spectrometry (MS)/MS reference libraries are essential for the comprehensive analysis of data-independent acquisition (DIA) MS datasets, providing a comprehensive set of spectra for identification and quantification of proteins. We have developed a novel web-based R-package (iSwathX) for combining reference libraries that is compatible with different DIA analysis software. This open-source web GUI automates the process of normalization and combination of spectral libraries and provides a user-friendly method for performing library format conversions, analysis and visualizations, with no need for programing familiarity. Availability and implementation iSwathX is freely accessible at https://biolinfo.shinyapps.io/iSwathX with the R-package and Shiny source code available from GitHub (https://github.com/znoor/iSwathX). Supplementary information Supplementary data are available at Bioinformatics online.
- Subjects
DATA mining; PEPTIDES; MASS spectrometry; PROTEIN-protein interactions; BIOINFORMATICS
- Publication
Bioinformatics, 2019, Vol 35, Issue 3, p538
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/bty660