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- Title
Genetic polymorphisms in the ITPKC gene and cervical squamous cell carcinoma risk.
- Authors
Yang, Yuh-Cheng; Chang, Tzu-Yang; Chen, Tze-Chien; Chang, Shih-Chuan; Chen, Wei-Fang; Chan, Hui-Wen; Lin, Wen-Shan; Wu, Fu-Ting; Lee, Yann-Jinn
- Abstract
Cervical cancer is caused primarily by infection with oncogenic types of human papillomavirus (HPV). However, HPV infection alone is not sufficient for the progression to cervical cancer. Host immunogenetic factors may involve in the development of this disease. Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is recently shown to act as a negative regulator of T-cell activation. We aim to study if polymorphisms in the ITPKC gene are associated with the risk of cervical cancer in Taiwanese women. ITPKC rs28493229 C/G, rs890934 G/T, rs2303723 C/T, and rs10420685 A/G polymorphisms were genotyped in a hospital-based study of 465 women with cervical squamous cell carcinoma (CSCC) and 800 age-matched healthy control women. The presence and genotypes of HPV in CSCC were determined. The frequency of G/G genotype and G allele of the ITPKC rs28493229 polymorphism was significantly higher in patients with CSCC compared with controls (OR = 1.81, 95 % CI 1.20-2.73, P = 0.005, P = 0.02; OR = 1.70, 95 % CI 1.14-2.54, P = 0.008, P = 0.03, respectively). No significant associations were found for other 3 polymorphisms. Haplotype analysis revealed the distribution of haplotype CGTA was significantly reduced in women with CSCC (OR = 0.59, 95 % CI 0.40-0.89, P = 0.01, P = 0.04). In conclusion, we found the G/G genotype and G allele of the ITPKC rs28493229 polymorphism may contribute to the risk of CSCC in Taiwanese women. This finding provides new insights into the mechanisms of immune activation in cervical cancer.
- Subjects
TAIWAN; GENETIC polymorphisms; CERVICAL cancer; DISEASES in women; SQUAMOUS cell carcinoma; PAPILLOMAVIRUSES; IMMUNOGENETICS; INOSITOL trisphosphate; CANCER risk factors
- Publication
Cancer Immunology, Immunotherapy, 2012, Vol 61, Issue 11, p2153
- ISSN
0340-7004
- Publication type
Article
- DOI
10.1007/s00262-012-1280-y