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- Title
Serum vitamin D/25(OH)D associated with toll-like receptor (TLR) 2 expression of immune cells in the saliva of Systemic Lupus Erythematosus: a preliminary study.
- Authors
Susanto, Hendri; Soebadi, Bagus; Ernawati, Diah Savitri; Pamardiati, Adiastuti Endah; Hendarti, Hening Tuti; Hernawan, Iwan; Radithia, Desiana; Awalia
- Abstract
Objective: Vitamin D deficiency may contribute to Systemic Lupus Erythematosus (SLE) development. Vitamin D may involve in pathogen recognition through Toll-like receptor (TLR) 2 in immune cells in saliva. This study aimed to determine the correlation between serum vitamin D/25(OH)D and TLR2 expression of immune cells in the saliva of SLE. Materials and methods: This cross-sectional study conducted at the the SLE patients who met the inclusion and exclusion criteria. Those who had signed informed consent involved to underwent unstimulated saliva collection and blood samples for TLR2 and vitamin D/25(OH)D examination. The correlation between serum vitamin D/25(OH)D concentration and salivary TLR2 expression was analyzed using the correlation test, linear regression with 95% confidence level. Results: Thirty SLE patients had a mean serum vitamin D/25(OH)D concentration of 9.98 ± 4.64 ng/ml. The mean of TLR2 expression of CD11b+ cells in saliva was 26.03 ± 20.92%. There was a significant positive correlation between serum vitamin D/25(OH)D concentration and TLR 2 expression of CD11b+ cells in the saliva. (r = 0.434; P < 0.05). Vitamin D/25(OH)D was the only predictor for TLR 2 expression. Conclusion: Serum vitamin D/25(OH)D concentrations associated with TLR2 expression of CD11b+ cells in the saliva of SLE.
- Subjects
ERGOCALCIFEROL; SYSTEMIC lupus erythematosus; TOLL-like receptors; SALIVA; VITAMINS; VITAMIN D deficiency
- Publication
Journal of Oral Medicine & Oral Surgery, 2021, Vol 27, Issue 2, p1
- ISSN
2608-1326
- Publication type
Article
- DOI
10.1051/mbcb/2020062