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- Title
Network meta-analysis of Chinese patent medicine combined with clomiphene citrate in the treatment of infertility caused by ovulation disorders.
- Authors
REN Mengxue; SUI Juan; QIN Yuling; BI Hong; CHEN Ziwei; ZHOU Lin; CHEN Ruixue
- Abstract
Objective: The purpose of this study was to evaluate the efficacy of different Chinese patent medicines com - bined with clomiphene citrate (CC) in the treatment of infertility caused by ovulation disorders, by using a network meta-analysis. Method: The relevant randomized controlled trialsr(RCTs) of Chinese patent medicines were retrieved from PubMed, EMbase, Cochrane Library, CBM, CNKI, Wanfang, and VIP Databas from the time of database establishment to February 2023, and Stata 16.0 was used for network meta-analysis. Result: A total of 30 RCTs were included in this study, involving 2 647 patients and 12 Chinese patent medicines. According to the results of network meta-analysis:in terms of improving endometrial thickness, improving ovulation rate and pregnancy rate, the effect of Dingkun Dan, Guipi Pill, Tiaojingcuyun Pill combined with CC is optimal respectively. Conclusion: The efficacy of the included Chinese medicines combined with CC in ovulation infertility was better than CC alone. However, because of the study's shortcomings, large-scale high-quality clinical trials are needed in the future research to be verified.
- Subjects
CHINESE medicine; OVULATION; INFERTILITY; CLOMIPHENE; CITRATES
- Publication
Journal of Hainan Medical University, 2024, Vol 30, Issue 7, p533
- ISSN
1007-1237
- Publication type
Article
- DOI
10.13210/j.cnki.jhmu.20230615.001