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- Title
Anticardiolipin Antibodies in Hemophiliac and Nonhemophiliac Patients with Chronic Hepatitis C.
- Authors
Zanon, Ezio; Pittoni, Marina; Vaselli, Giorgina; Tagariello, Giuseppe; Girolami, Bruno; Saracino, Maria A.; Girolami, Antonio
- Abstract
Anticardiolipin antibodies (ACA) have been detected in a variety of infectious diseases, especially viral infections. ACA also have been described in human immunodeficiency virus (HIV)-infected hemophiliacs. Recently, the presence of ACA in hemophiliac and nonhemophiliac patients with chronic hepatitis C virus has been reported. We preformed a case-controlled study to establish if ACA are present in hemophilia and if they are due to the hepatitis C infection; and to confirm the association between the ACA and hepatitis C infections in nonhemophiliac patients. Anticardiolipin antibodies have been studied in the serum of 62 hemophiliacs with chronic hepatitis C virus and in the control group (70 hepatitis C-negative patients with hemophilia or other clotting disorders). ACA were positive in only three hepatitis C-positive hemophiliac patients and in three hepatitis C-negative patients with hemophilia or other coagulation defects (first control group). No significant statistical differences were found in the groups (OR = 1.1;95% CI 0.2-7.4, p = .6) Sixteen of the 111 nonhemophiliacs with chronic hepatitis C were positive for ACA while 100 matched hepatitis C-negative subjects (second control group) anticardiolipin antibodies were positive in 9 patients. ACA tended to be higher in hepatitis C-positive nonhemophiliac patients than in the control group, but the difference between the two groups was not statistically significant (OR = 1.7, 95% CI 0.7-4.4, p = .3) ACA do not seem to be associated with the chronic hepatitis C virus.
- Subjects
HEPATITIS C; VIRAL hepatitis; IMMUNOGLOBULINS; COMMUNICABLE diseases; HEMOPHILIA
- Publication
Clinical & Applied Thrombosis/Hemostasis, 1998, Vol 4, Issue 3, p205
- ISSN
1076-0296
- Publication type
Article
- DOI
10.1177/107602969800400311