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- Title
Polar body biopsy: a viable alternative to preimplantation genetic diagnosis and screening.
- Authors
Montag, M.; Van der Ven, K.; Rösing, B.; Van der Ven, H.
- Abstract
Polar body diagnosis (PBD) is a diagnostic method for the indirect genetic analysis of oocytes. Polar bodies are by-products of the meiotic cell cycle, which have no influence on further embryo development. The biopsy of polar bodies can be accomplished either by zona drilling or laser drilling within a very short time period. However, the paternal contribution to the genetic constitution of the developing embryo cannot be diagnosed by PBD. The major application of PBD is the detection of maternally derived chromosomal aneuploidies and translocations in oocytes. For these indications, PBD may offer a viable alternative to blastomere biopsy as the embryo's integrity remains unaffected, in contrast to preimplantation genetic diagnosis (PGD) by blastomere biopsy. The rapid pace of developments in the field of molecular diagnostics will also influence the advantages of PBD, and probably allow more general diagnostic applications in the future.
- Subjects
BIOPSY; PREIMPLANTATION genetic diagnosis; OVUM; MEIOSIS; HUMAN embryos; MOLECULAR diagnosis; DIAGNOSIS
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2009, Vol 18, Issue S1, p6
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/S1472-6483(10)60109-5