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- Title
Relationship between Maternal Ageand the Incidence of Down Syndrome.
- Authors
REGITA, AUDYA TYAS; PRIMARTI, RISTI SAPTARINI; RIYANTI, ERISKA; ACHMAD, HARUN
- Abstract
Introduction: Down syndrome is the most common genetic disorder in the world caused by abnormalities in the chromosome. Genetic disorders can be caused by trisomy 21, translocation, and mosaic. Trisomy 21 is characterized by an excess number of the 21st chromosomedue to the nondisjunction where 21st chromosome fails to separate from the homologous chromosome; the incidence reaches 95% of the total Down Syndrome incidences in the world. Down syndrome is a multifactorial disease, including maternal and paternal age, environment, radiationsand chemicals. The most common factor that increases the risk of Down syndrome is the age of mother. Aim: The aim of this study was todetermine the relationship of maternal age with the incidence of Down Syndrome in Karawang Regency. Method: Analytic observation method was used in this research with a case-control design. Data analysis was calculated using Chi-square test with p-value <a (0,000 <0,05.) The risk was calculated using Odd Ratio. Purposive sampling techniques was used todeterminespecific characteristics in accordance with the objectives of the study. The study sample consisted of 38 mothers with Down Syndrome children and 59 mothers with normal children as control variables. Results: A significant relationship is shown between maternalage and the incidence of Down Syndrome. Odd Ratio value of 9,815 showedmothers who give birthat >35 years old have 9.815 times greater risk compared to mothers who give birth at ≤35. Conclusion: There is a significant relationship between maternal age and the incidence of Down syndrome in Karawang.
- Subjects
DOWN syndrome; CHROMOSOMES; CHI-squared test; DATA analysis; MATERNAL age
- Publication
International Journal of Pharmaceutical Research (09752366), 2020, p753
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2020.SP3.105