We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
T-cell-antigen recognition and the immunological synapse.
- Authors
Huppa, Johannes B.; Davis, Mark M.
- Abstract
Much excitement of the past five years in the area of T-cell-antigen recognition has centred around the immunological synapse - a complex cellular structure that forms at the interface of a T cell and a cell that expresses the appropriate peptide-MHC complexes. Thanks to new imaging technologies, we are now beginning to understand the role of cell-surface molecules and some of their attendant signalling modules in the context of cell-to-cell communication. Progress has been so rapid that T-cell-antigen recognition might be the first system in which the molecular basis of cell-cell recognition is understood.
- Subjects
T cells; ANTIGENS; IMMUNE response; PEPTIDES; IMMUNOLOGY
- Publication
Nature Reviews Immunology, 2003, Vol 3, Issue 12, p973
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri1245