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- Title
CROSS-PRESENTATION IN VIRAL IMMUNITY AND SELF-TOLERANCE.
- Authors
Heath, William R.; Carbone, Francis R.
- Abstract
T lymphocytes recognize peptide antigens presented by class I and class II molecules encoded by the major histocompatibility complex (MHC). Classical antigen-presentation studies showed that MHC class I molecules present peptides derived from proteins synthesized within the cell, whereas MHC class II molecules present exogenous proteins captured from the environment. Emerging evidence indicates, however, that dendritic cells have a specialized capacity to process exogenous antigens into the MHC class I pathway. This function, known as cross-presentation, provides the immune system with an important mechanism for generating immunity to viruses and tolerance to self.
- Subjects
T cells; ANTIGENS; MAJOR histocompatibility complex; DENDRITIC cells; IMMUNITY
- Publication
Nature Reviews Immunology, 2001, Vol 1, Issue 2, p126
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/35100512