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- Title
The Impact of Isotretinoin on Platelet and White Blood Cell Count in Patients with Acne Vulgaris.
- Authors
Abdulwahab, Mayday Hadi; Jawad, Alaa Abdul sahib
- Abstract
Background: Acne is a multifactorial inflammatory disorder and represents a spectrum range from a pair of blackheads and pustules to severe nodulocystic fulminant acne. The severity of the disease differs from patient to patient; therefore, For the treatment of acne, isotretinoin is frequently utilized. Isotretinoin, however, may cause triglyceride and cholesterol levels in the blood to rise and may interfere with liver function tests. Also, the impact of isotretinoin on hematological parameters is still debatable and is examined by looking at alterations to the blood chemistry profile and haematological parameters of acne patients who are on isotretinoin. This study was aimed to show the effect of Isotretinoin on WBC and platelet count in a patient with acne vulgaris. Methods: This comparative study was conducted in a Clinic at the Department of Dermatology in two hospitals, Salahaddin hospital and the general hospital, in Tikrit city, Iraq. One hundred sixteen patients were selected. Patients suffer from acne and are divided equally (58 patients each) into one of the two treatment regimens (Isotretinoin and doxycycline). Group one was given oral Isotretinoin 0.5mg/kg divided twice daily for six months, and Group two was given doxycycline 100 mg twice daily for the same period. Results: Among the 116 cases included in the study, (36) were male, and (80) were female. The mean age of group one was 21.97±4.87 years, and in group two, it was 21.72±4.95years. The mean platelet counts increased, whereas the white blood cell count decreased after isotretinoin treatment. But without any statically significant association. Conclusions: This study's results revealed no statistically significant effect of white blood cells and platelet count after therapy by Isotretinoin.
- Subjects
TIKRIT (Iraq); IRAQ; LEUKOCYTE count; BLOOD platelets; ACNE; ISOTRETINOIN; LIVER function tests
- Publication
Kerbala Jorunal of Medicine, 2022, Vol 15, Issue 2, p2601
- ISSN
1990-5483
- Publication type
Article