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- Title
General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain.
- Authors
Wen-Xin Hang; Yan-Chang Yang; Yu-Han Hu; Fu-Quan Fang; Lang Wang; Xing-Hua Qian; McQuillan, Patrick M.; Hui Xiong; Jian-Hang Leng; Zhi-Yong Hu
- Abstract
General anesthetic agents can impact brain function through interactions with neurons and their effects on glial cells. Oligodendrocytes perform essential roles in the central nervous system, including myelin sheath formation, axonal metabolism, and neuroplasticity regulation. They are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation, differentiation, and apoptosis. Neurologists are increasingly interested in the effects of general anesthetic agents on oligodendrocytes. These agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways, but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and function. In this review, we summarize the effects of general anesthetic agents on oligodendrocytes. We anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.
- Subjects
ANESTHETICS; MYELINATION; CENTRAL nervous system; OLIGODENDROGLIA; NEUROTOXICOLOGY; MYELIN sheath; NEUROGLIA
- Publication
Zoological Research, 2024, Vol 45, Issue 3, p691
- ISSN
2095-8137
- Publication type
Article
- DOI
10.24272/j.issn.2095-8137.2023.413