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- Title
An efficient click synthesis of chalcones derivatized with two 1-(2-quinolon-4-yl)-1,2,3-triazoles.
- Authors
Alshammari, Mohammed B.; Aly, Ashraf A.; Brown, Alan B.; Bakht, Md Afroz; Shawky, Ahmed M.; Abdelhakem, Adel M.; El-Sheref, Essmat M.
- Abstract
Chalcones derivatized with 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 4-azido-2-quinolones with 1-phenyl-3-(4-propargyloxyphenyl)prop-2-en-1-one, or by aldol reaction of 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes with acetophenone. Whereas, chalcones bearing two 1-(2-quinolonyl)-1,2,3-triazoles were synthesized by reaction of 1,3-bis(4-propargyloxyphenyl)prop-2-en-1-one with 4-azido-2-quinolones, or by aldol condensation between 4-{4-[(4-acetylphenoxy)methyl]-1H-1,2,3-triazol-1-yl}quinolin-2(1H)-ones and 4-{[1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzaldehydes.
- Subjects
CHALCONES; ALDOL condensation; ACETOPHENONE; CHALCONE
- Publication
Zeitschrift für Naturforschung B: A Journal of Chemical Sciences, 2021, Vol 76, Issue 6/7, p395
- ISSN
0932-0776
- Publication type
Article
- DOI
10.1515/znb-2021-0028