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- Title
Analysis of the Role of Plasma 25‐Hydroxyvitamin D Levels in Survival Outcomes in Patients from the Phase III MPACT Trial of Metastatic Pancreatic Cancer.
- Authors
Von Hoff, Daniel D.; Cridebring, Derek; Tian, Olivia Yu; Han, Haiyong; Bhore, Rafia; Franco, Twyla; Ondovik, Michael S.; Louis, Chrystal U.
- Abstract
Background: We examined overall survival (OS) outcomes based on plasma 25‐hydroxyvitamin D [25(OH)D] levels in this post hoc analysis of the phase III MPACT trial of metastatic pancreatic cancer. Materials and Methods: Patients were subdivided based on 25(OH)D level: sufficient (≥30 ng/mL), relatively insufficient (20–<30 ng/mL), or insufficient (<20 ng/mL). Results: Of 861 patients randomized in MPACT, 422 were included in this analysis. In the all‐patients group, the median OS among those with insufficient, relatively insufficient, and sufficient 25(OH)D levels was 7.9, 9.4, and 7.8 months, respectively. No statistically significant OS difference was observed with relatively insufficient (p =.227) or sufficient (p =.740) versus insufficient 25(OH)D levels or with sufficient vs relatively insufficient (p =.301) 25(OH)D levels. Conclusion: No association was observed between plasma 25(OH)D levels and survival. Further investigations are needed to understand any role of vitamin D in pancreatic cancer. Clinical trial identification number. NCT00844649. Studies have suggested a possible survival benefit for patients with pancreatic cancer and sufficient vitamin D levels. This article examines potential correlations between plasma 25‐hydroxyvitamin D levels and overall survival outcomes in patients from the MPACT trial.
- Subjects
PANCREATIC tumors; SURVIVAL; METASTASIS; VITAMIN D; TREATMENT effectiveness; RANDOMIZED controlled trials; CANCER patients; DESCRIPTIVE statistics; VITAMIN D deficiency
- Publication
Oncologist, 2021, Vol 26, Issue 4, pe704
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1002/onco.13645