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- Title
Cerebrospinal fluid analysis and the determination of oligoclonal bands.
- Authors
Gastaldi, Matteo; Zardini, Elisabetta; Leante, Rosaria; Ruggieri, Maddalena; Costa, Gianna; Cocco, Eleonora; Luca, Giovanna; Cataldo, Ivana; Biagioli, Tiziana; Ballerini, Clara; Castellazzi, Massimiliano; Fainardi, Enrico; Pettini, Paola; Zaffaroni, Mauro; Giunti, Debora; Capello, Elisabetta; Bernardi, Gaetano; Ciusani, Emilio; Giannotta, Claudia; Nobile-Orazio, Eduardo
- Abstract
This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.
- Subjects
CEREBROSPINAL fluid examination; OLIGOCLONAL bands; NEUROIMMUNOLOGY; ISOELECTRIC focusing; CLINICAL pathology; QUESTIONNAIRES; CNS demyelinating autoimmune diseases
- Publication
Neurological Sciences, 2017, Vol 38, p217
- ISSN
1590-1874
- Publication type
journal article
- DOI
10.1007/s10072-017-3034-2