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- Title
An eye on the news – a case report.
- Authors
Moraru, Mihaela; Goga, Iolanda; Nichita, Adriana-Monica; Cioc, Enache; Ilie, Maria-Andreea; Zob, Daniela-Luminiţa; Stănculeanu, Dana-Lucia; Ionescu, Andreea; Gheorghe, Adelina-Silvana; Dumitrescu, Elena-Adriana
- Abstract
Ocular melanoma is a rare and aggressive form of eye cancer, with limited treatment options. Tebentafusp is a breakthrough immunotherapy that has attracted attention for its unique approach to treating ocular melanoma. This abstract describes the compelling case of a woman previously treated for uveal melanoma with ocular brachytherapy who later presented with challenging liver metastases. After a two-year interval, she underwent a series of investigations, including a liver biopsy, which confirmed the presence of liver steatosis. Unfortunately, after a four-year interval, magnetic resonance imaging (MRI) and positron emission tomography (PET-CT) showed nodular liver lesions. Surgical intervention confirmed the liver metastasis, and within a remarkably short period of two months, the liver metastasis recurred. A positive HLA-A*02:01 test led to the decision to initiate systemic therapy with tebentafusp. The first five doses were administered in the intensive care unit, under close supervision. Despite side effects such as skin rashes and fever, neither cytokine release syndrome, nor prolongation of the QT interval occurred. After two months, the abdominal MRI showed the improvement of liver lesions and the PET-CT scan indicated no further lesions. In conclusion, the decision to initiate systemic therapy with tebentafusp resulted in positive outcomes, despite the possibility of severe side effects.
- Subjects
UVEA cancer; POSITRON emission tomography computed tomography; EYE cancer; POSITRON emission tomography; CYTOKINE release syndrome; LIVER metastasis
- Publication
Oncolog-Hematolog, 2023, Issue 64, p40
- ISSN
2066-8716
- Publication type
Article