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- Title
3‴- O -Foliamenthoyl-Rutin, a New Flavonoid Glycoside from the Roots of Nymphoides peltata.
- Authors
Kim, Tae-Young; Lee, Bum Soo; Jo, Beom-Geun; Heo, Seong Pil; Keem, Min-Ji; Kwon, Taek-Hwan; Kim, Su-Nam; Kim, Ki Hyun; Yang, Min Hye
- Abstract
Nymphoides peltata (Menyanthaceae) has been used as a medicinal herb in traditional medicines to treat conditions such as strangury, polyuria, swelling, and as a diuretic and antipyretic. In our ongoing research to discover novel structural and/or biological natural products in natural resources, five flavonoids, quercetin (1), quercitrin (2), isoquercetin (3), quercetin-3-O-vicianoside (4), and rutin (5), as well as a new flavonoid glycoside, 3‴-O-foliamenthoyl-rutin (6), were isolated from the MeOH extract of N. peltata roots. The chemical structure of the new compound (6) was determined by analyzing 1D and 2D NMR spectra and high-resolution (HR) electrospray ionization mass spectroscopy (ESIMS), along with a chemical reaction. The wound-healing activities of the isolated compounds (1–6) were evaluated using a HaCaT cell scratch test. Among the isolates, isoquercetin (3), quercetin-3-O-vicianoside (4), and 3‴-O-foliamenthoyl-rutin (6) promoted HaCaT cell migration over scratch wounds, with compound 4 being the most effective. Our findings provide experimental data supporting the potential of quercetin-3-O-vicianoside (4) as a wound-healing agent.
- Subjects
FLAVONOID glycosides; BIOLOGICAL products; NATURAL products; CHEMICAL reactions; QUERCETIN; MASS spectrometry; HERBAL medicine; FLAVONOIDS
- Publication
Plants (2223-7747), 2023, Vol 12, Issue 24, p4083
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants12244083