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- Title
A Mixture of Kaempferol-3- O -sambubioside and Kaempferol-3- O -sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes.
- Authors
Campos-Vidal, Yrvinn; Zamilpa, Alejandro; Jiménez-Ferrer, Enrique; Jiménez-Aparicio, Antonio Ruperto; Camacho-Díaz, Brenda Hildeliza; Trejo-Tapia, Gabriela; Tapia-Maruri, Daniel; Monterrosas-Brisson, Nayeli; Herrera-Ruiz, Maribel
- Abstract
Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.
- Subjects
SPRAGUE Dawley rats; GASTROINTESTINAL diseases; INFLAMMATION; TRADITIONAL medicine
- Publication
Plants (2223-7747), 2022, Vol 11, Issue 21, p2951
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants11212951