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- Title
Enhancement of skin permeation of vitamin C using vibrating microneedles.
- Authors
Cho-A Lee; Jong-Suep Baek; Dong-Gi Kwag; Hye-Jin Lee; Jeanho Park; Cheong-Weon Cho
- Abstract
This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In vitro permeation by vitamin C was evaluated according to the specific conditions such as vibration intensity (levels 1, 2 and 3), application time (1, 3, 5, 7 and 10 min), and application power (500, 700 and 1,000 g). The highest permeation of vitamin C was observed at level 3 of vibration intensity, 5 min of application, and 1,000 g of application power. Vitamin C gel showed no cytotoxic effect against Pam212 cells or skin irritation effects. A pharmacokinetic study of the gel in rats was conducted under optimized conditions. The AUC0-∞ and Cmax increased 1.35-fold and 1.44-fold, respectively, compared with those after vitamin C gel without application with vibrating microneedles. The present study suggests that vibrating microneedles can be used to facilitate the skin permeability of vitamin C under optimal conditions.
- Subjects
SKIN permeability; PHYSIOLOGICAL effects of vitamin C; NEEDLES &; pins
- Publication
Translational & Clinical Pharmacology, 2017, Vol 25, Issue 1, p15
- ISSN
2289-0882
- Publication type
Article
- DOI
10.12793/tcp.2017.25.1.15