Creatine kinase (CK/CK‐MB) testing is an essential laboratory test approaching a patient with chest or epigastric pain. We report a 38‐year‐old man with acute pancreatitis and elevated CK/CK‐MB level without myocardial involvement. Acute pancreatitis may be considered as a false‐positive cause of CK/CK‐MB test in patients presenting with chest pain.