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- Title
NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling.
- Authors
Britton, Heidi M.; Levine, Adrian B.; Shen, Yaoqing; Mungall, Karen; Serrano, Jonathan; Snuderl, Matija; Pleasance, Erin; Jones, Steven J. M.; Laskin, Janessa; Marra, Marco A.; Rassekh, Shahrad R.; Deyell, Rebecca; Yip, Stephen; Cheng, Sylvia; Dunham, Chris
- Abstract
This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.
- Subjects
GLIOBLASTOMA multiforme; GENOMES; CANCER treatment; ONCOGENES
- Publication
Clinical Case Reports, 2021, Vol 9, Issue 3, p1472
- ISSN
2050-0904
- Publication type
Article
- DOI
10.1002/ccr3.3804