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- Title
Immuno-histologic and histomorphometric evaluation of Angelica sinensis adjunctive to ß-tricalcium phosphate in critical-sized class II furcation defects in dogs.
- Authors
Eldeeb, Dina W.; Hommos, Ahmed M.; Taalab, Maha R.; Abd El Rehim, Samia S.
- Abstract
Objective: The study evaluates the effectiveness of Angelica sinensis (As) adjunctive to Beta-tricalcium phosphate (β-TCP) bone graft in the management of induced critical sized class II furcation defects in dogs. Material and method: A randomized study design was conducted on the third and fourth premolars of six dogs. A total of twenty-four defects were surgically created. After reflecting a mucoperiosteal flap, twelve defects were filled with As granules mixed with β-TCP (Experimental group) while the other twelve defects were filled with β-TCP only (Control group) and both were covered by collagen membrane. At the fourth and eighth weeks, jaw segments were dissected and processed for immune-histological examination and histomorphometry analysis. Results: At four and eight weeks after treatment, experimental group showed a statistically significant increase in the height of newly formed interradicular bone (p = 0.001 and p = 0.0001 respectively), its surface area (p = 0.002 and p = 0.02 respectively), and the thickness of its trabeculae (p = 0.0001 and p = 0.001 respectively), when compared to control group. Moreover. alkaline phosphatase immunoreaction showed higher intensity in the osteoblast cells of experimental group compared to control group. Conclusion: As enhances periodontal regeneration and bone-formation when used in the management of furcation defects.
- Subjects
DONG quai; DOGS; ALKALINE phosphatase; EXPERIMENTAL groups; BONE grafting
- Publication
BDJ Open, 2023, Vol 9, Issue 1, p1
- ISSN
2056-807X
- Publication type
Article
- DOI
10.1038/s41405-023-00150-y