We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comment on "Ventricular Arrhythmias Following Exposure of Failing Hearts to Oxidative Stress In Vitro"
- Authors
KNISLEY, STEPHEN B.
- Abstract
This article presents comments of the author on the article "Ventricular Arrhythmias Following Exposure of Failing Hearts to Oxidative Stress in Vitro," published in the June 1, 2005 issue of the "Journal of Cardiovascular Electrophysiology." The article represents an important step in the search for the triggering factors that play a role in lethal tachyarrhythmias in heart failure. Despite the fact that heart failure carries a high risk of death or hospital readmission, the cause of death and the optimal therapy remain elusive. The production and use of an animal model of heart failure can be an especially difficult and costly enterprise. Experimental reports of the effects of failure or the conditions produced in a particular model of failure have described changes in cardiac variables including ion channels, pumps or exchangers, action potentials, reactive oxygen species, and ventricular function. However, information on the arrhythmias themselves is essential for understanding the cause of death in failure, developments of potential therapeutic strategies, and whether proposed mechanisms apply to genesis of lethal arrhythmias.
- Subjects
ARRHYTHMIA; VENTRICULAR tachycardia; HEART diseases; HEART failure; OXIDATIVE stress; ELECTROPHYSIOLOGY
- Publication
Journal of Cardiovascular Electrophysiology, 2005, Vol 16, Issue 6, p637
- ISSN
1045-3873
- Publication type
Editorial
- DOI
10.1111/j.1540-8167.2005.40818.x