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- Title
Comparing high and low levels of continuous positive airway pressure on lung aeration in patients with pleural drainage: A feasibility study for a randomized controlled trial.
- Authors
Santos, Elinaldo da Conceição; Pontes Campos, Achiles Eduardo; Carmo, Odielson Ferreira; Lunardi, Adriana Claudia
- Abstract
Objective: We explored the feasibility of use of continuous positive airway pressure (CPAP) with 15‐ and 4‐cmH2O for a randomized controlled trial with patients with pleural drainage. Methods: Ten patients with traumatic pleural effusion drained within 24 hr, with controlled pain received randomly CPAP with 0‐, 4‐, and 15‐cmH2O. Computed tomography was used to assess the lung aeration. Patients reported the level of tolerability. Air leak was also observed as a parameter of safety. The levels of pressure were compared using the Friedman test followed by the Tukey test as post hoc. Results: The lung area under CPAP with 15 cmH2O (median = 3,913 mm2; IQR = 3,416–4,390 mm2) was greater than 4 (median = 3,495 mm2; IQR = 3,075–3,954 mm2) and 0 cmH2O (median = 3,382 mm2; IQR = 2,962–3,658 mm2; p < 0.001). There was no difference between lung areas under CPAP with 4 and 0 cmH2O. All levels of pressure were well tolerated by patients. No air leak was observed during the assessments. Conclusion: CPAP with 15 cmH2O is able to expand lungs of patients with pleural drainage. CPAP with 4 cmH2O seems not have therapeutic effect. In addition, CPAP with 15 cmH2O is well tolerated and safe in this population.
- Subjects
LUNG physiology; COMPARATIVE studies; COMPUTED tomography; PLEURAL effusions; STATISTICS; T-test (Statistics); PILOT projects; DATA analysis; RANDOMIZED controlled trials; TREATMENT effectiveness; CONTINUOUS positive airway pressure; DATA analysis software; DESCRIPTIVE statistics; MEDICAL drainage; FRIEDMAN test (Statistics)
- Publication
Physiotherapy Research International, 2019, Vol 24, Issue 1, pN.PAG
- ISSN
1358-2267
- Publication type
Article
- DOI
10.1002/pri.1753