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- Title
Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study.
- Authors
Zinellu, Angelo; Zoroddu, Stefano; Fois, Simona; Mellino, Sabrina; Scala, Chiara; Virdis, Erika; Zinellu, Elisabetta; Sotgia, Salvatore; Paliogiannis, Panagiotis; Mangoni, Arduino A.; Carru, Ciriaco; Pirina, Pietro; Fois, Alessandro G.
- Abstract
There are increasing efforts to better predict adverse outcomes for idiopathic pulmonary fibrosis (IPF). Our aim was to assess the prognostic potential of ischemia-modified albumin (IMA), an established circulating marker of ischemia and, more recently, oxidative stress, in a cohort of 56 IPF patients recruited between 2015 and 2023 at the University of Sassari, Italy. Demographic and functional parameters and serum IMA concentrations were measured at baseline. Non-survivors had significantly higher IMA concentrations vs. survivors (508 ± 64 vs. 474 ± 42 mABSU, respectively; p = 0.035). The Kaplan–Meier analysis showed a significant association between higher IMA values and poor survival (HR: 3.32, 95% CI from 1.06 to 10.4, p = 0.039). In the Cox regression analysis, this association remained significant after adjusting for the force expiratory volume at 1 s, the total lung capacity, lymphocyte count, and pharmacological treatment (HR: 1.0154, 95% CI from 1.0035 to 1.0275, p = 0.01). IMA, an oxidative stress biomarker measurable using relatively simple and available methods, is independently associated with mortality in IPF. Therefore, its determination may enhance risk stratification and treatment decisions. Prospective studies involving larger cohorts are needed to confirm this association and to endorse the use of IMA in routine practice.
- Subjects
ITALY; IDIOPATHIC pulmonary fibrosis; UNIVERSITY of Sassari; OVERALL survival; ALBUMINS; LYMPHOCYTE count; PILOT projects
- Publication
Antioxidants, 2024, Vol 13, Issue 3, p278
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox13030278