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- Title
Manifestations of oxidative stress and liver injury in clothianidin exposed Oncorhynchus mykiss.
- Authors
Dogan, Demet; Deveci, Haci Ahmet; Nur, Gokhan
- Abstract
This investigation was conducted to evaluate the effects of clothianidin, a neonicotinoid insecticide, on hepatic oxidative stress biomarkers, biochemical indices of blood serum and liver integrity in juvenile Oncorhynchus mykiss following 7, 14 and 21 days of application to environmentally relevant concentrations of 3, 15 and 30 µg/l. The observed hypertrophy caused elevation in hepatosomatic index, a significant increase in serum glucose and a decrease in tissue protein level with extended period of exposure were determined. The treatment resulted in a marked induction in the activities of antioxidant enzymes which were accompanied with simultaneous elevation in MDA and protein carbonyl level ref lecting loss of membrane integrity and protein function. Histopathological examination showed liver injury manifested as hepatocellular degeneration, fibrosis, vacuolation, congestion, necrosis, steatosis and pyknosis proceding with the concentration. The stressful condition triggered hyperglycemic and hypoproteinemic conditions which might be proposed as general adaptive response. Moreover, altered liver histology reveals the hepatotoxic potential of clothianidin via oxidative stress as a common pathological mechanism leading to liver injury.
- Subjects
OXIDATIVE stress; CLOTHIANIDIN; LIVER injuries; BIOMARKERS; RAINBOW trout
- Publication
Toxicology Research, 2021, Vol 10, Issue 3, p501
- ISSN
2045-452X
- Publication type
Article
- DOI
10.1093/toxres/tfab027