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IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071476
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- Publication type:
- Article
Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier.
- Published in:
- Biotechnology & Bioengineering, 2007, v. 97, n. 6, p. 1376, doi. 10.1002/bit.21369
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- Publication type:
- Article
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier.
- Published in:
- Biotechnology & Bioengineering, 2007, v. 96, n. 2, p. 381, doi. 10.1002/bit.21120
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- Publication type:
- Article
Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (<italic>valanafusp alpha</italic>): an open label phase 1-2 trial
- Published in:
- 2018
- By:
- Publication type:
- journal article
Vascular Genomics of the Human Brain.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2002, v. 22, n. 3, p. 245, doi. 10.1097/00004647-200203000-00001
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- Publication type:
- Article
Cloned Blood-Brain Barrier Adenosine Transporter Is Identical to the Rat Concentrative Na<sup>+</sup> Nucleoside Cotransporter CNT2.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2001, v. 21, n. 8, p. 929, doi. 10.1097/00004647-200108000-00005
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- Publication type:
- Article
Blood-Brain Barrier Genomics.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2001, v. 21, n. 1, p. 61, doi. 10.1097/00004647-200101000-00008
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- Publication type:
- Article
Selective Lutheran Glycoprotein Gene Expression at the Blood-Brain Barrier in Normal Brain and in Human Brain Tumors.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2000, v. 20, n. 7, p. 1096, doi. 10.1097/00004647-200007000-00009
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- Publication type:
- Article
Insulin receptor antibody-iduronate 2-sulfatase fusion protein: Pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys.
- Published in:
- Biotechnology & Bioengineering, 2014, v. 111, n. 11, p. 2317, doi. 10.1002/bit.25289
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- Publication type:
- Article
Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor.
- Published in:
- Biotechnology & Bioengineering, 2013, v. 110, n. 5, p. 1456, doi. 10.1002/bit.24795
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- Publication type:
- Article
Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein.
- Published in:
- Biotechnology & Bioengineering, 2011, v. 108, n. 8, p. 1954, doi. 10.1002/bit.23118
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- Publication type:
- Article
CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein.
- Published in:
- Biotechnology & Bioengineering, 2011, v. 108, n. 1, p. 186, doi. 10.1002/bit.22907
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- Publication type:
- Article
IgG-single chain Fv fusion protein therapeutic for alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey.
- Published in:
- Biotechnology & Bioengineering, 2010, v. 105, n. 3, p. 627, doi. 10.1002/bit.22576
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- Publication type:
- Article
Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse.
- Published in:
- Biotechnology & Bioengineering, 2009, v. 102, n. 4, p. 1251, doi. 10.1002/bit.22135
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- Publication type:
- Article
GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier.
- Published in:
- Biotechnology & Bioengineering, 2008, v. 100, n. 2, p. 387, doi. 10.1002/bit.21764
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- Publication type:
- Article
Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier.
- Published in:
- Biotechnology & Bioengineering, 2008, v. 99, n. 2, p. 475, doi. 10.1002/bit.21602
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- Publication type:
- Article
The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier.
- Published in:
- Journal of Drug Delivery, 2011, p. 1, doi. 10.1155/2011/296151
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- Publication type:
- Article
Immunologic privilege in the central nervous system and the blood-brain barrier.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2013, v. 33, n. 1, p. 13, doi. 10.1038/jcbfm.2012.153
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- Publication type:
- Article
Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 10, p. 1933, doi. 10.1038/jcbfm.2012.97
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- Publication type:
- Article
Blood–brain barrier genomics and cloning of a novel organic anion transporter.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2008, v. 28, n. 2, p. 291, doi. 10.1038/sj.jcbfm.9600538
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- Publication type:
- Article
Rat Blood-Brain Barrier Genomics. II.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2002, v. 22, n. 11, p. 1319, doi. 10.1097/00004647-200211000-00005
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- Publication type:
- Article
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-55136-4
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- Publication type:
- Article
Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia.
- Published in:
- 1995
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- Publication type:
- journal article
Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter.
- Published in:
- Journal of Gene Medicine, 2008, v. 10, n. 3, p. 306, doi. 10.1002/jgm.1152
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- Publication type:
- Article
Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes.
- Published in:
- Journal of Gene Medicine, 2007, v. 9, n. 7, p. 605, doi. 10.1002/jgm.1046
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- Publication type:
- Article
Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice.
- Published in:
- Journal of Gene Medicine, 2004, v. 6, n. 8, p. 906, doi. 10.1002/jgm.575
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- Publication type:
- Article
In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats.
- Published in:
- Journal of Gene Medicine, 2003, v. 5, n. 12, p. 1039, doi. 10.1002/jgm.449
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- Publication type:
- Article
Marked enhancement in gene expression by targeting the human insulin receptor.
- Published in:
- Journal of Gene Medicine, 2003, v. 5, n. 2, p. 157, doi. 10.1002/jgm.333
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- Publication type:
- Article
Receptor-mediated delivery of an antisense gene to human brain cancer cells.
- Published in:
- Journal of Gene Medicine, 2002, v. 4, n. 2, p. 183, doi. 10.1002/jgm.255
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- Publication type:
- Article
Hematologic safety of chronic brain‐penetrating erythropoietin dosing in APP/PS1 mice.
- Published in:
- Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2019, v. 5, n. 1, p. 627, doi. 10.1016/j.trci.2019.09.003
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- Publication type:
- Article
Diphenylhydantoin Stimulates the Intrapituitary Conversion of Thyroxine to Triiodothyronine in the Rat.
- Published in:
- Neuroendocrinology, 1992, v. 56, n. 4, p. 453, doi. 10.1159/000126261
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- Publication type:
- Article
Evidence Suggesting that the Sympathetic Nervous System Mediates Thyroidal Depression in Turpentine-Induced Nonthyroidal Illness Syndrome.
- Published in:
- Neuroendocrinology, 1991, v. 53, n. 4, p. 360, doi. 10.1159/000125742
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- Publication type:
- Article
Role of the Sympathetic Nervous System in the Control of Thyroid Compensatory Growth of Normal and Hypophysectomized Rats.
- Published in:
- Neuroendocrinology, 1985, v. 40, n. 4, p. 309, doi. 10.1159/000124092
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- Publication type:
- Article
Measurement of Blood-Brain Barrier GLUT1 Glucose Transporter and Actin mRNA by a Quantitative Polymerase Chain Reaction Assay.
- Published in:
- Journal of Neurochemistry, 1994, v. 62, n. 6, p. 2085, doi. 10.1046/j.1471-4159.1994.62062085.x
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- Publication type:
- Article
Glucose Deprivation Causes Posttranscriptional Enhancement of Brain Capillary Endothelial Glucose Transporter Gene Expression via GLUT1 mRNA Stabilization.
- Published in:
- Journal of Neurochemistry, 1993, v. 60, n. 6, p. 2290, doi. 10.1111/j.1471-4159.1993.tb03516.x
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- Publication type:
- Article
A One-Step Procedure for Isolation of Poly(A)<sup>+</sup> mRNA from Isolated Brain Capillaries and Endothelial Cells in Culture.
- Published in:
- Journal of Neurochemistry, 1991, v. 57, n. 6, p. 2136, doi. 10.1111/j.1471-4159.1991.tb06433.x
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- Publication type:
- Article
Hypoxia induces de-stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells.
- Published in:
- Journal of Neurochemistry, 2003, v. 85, n. 4, p. 1037, doi. 10.1046/j.1471-4159.2003.01757.x
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- Publication type:
- Article
Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234.
- Published in:
- Journal of Neurochemistry, 2003, v. 84, n. 6, p. 1322, doi. 10.1046/j.1471-4159.2003.01622.x
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- Publication type:
- Article
Site-Directed Deletion of a 10-Nucleotide Domain of the 3′-Untranslated Region of the GLUT1 Glucose Transporter mRNA Eliminates Cytosolic Protein Binding in Human Brain Tumors and Induction of Reporter Gene Expression.
- Published in:
- Journal of Neurochemistry, 1997, v. 68, n. 6, p. 2587, doi. 10.1046/j.1471-4159.1997.68062587.x
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- Publication type:
- Article
Evidence for Translational Control Elements Within the 5′-Untranslated Region of GLUT1 Glucose Transporter mRNA.
- Published in:
- Journal of Neurochemistry, 1996, v. 67, n. 4, p. 1335, doi. 10.1046/j.1471-4159.1996.67041335.x
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- Publication type:
- Article
Cis-Element/Cytoplasmic Protein Interaction Within the 3′-Untranslated Region of the GLUT1 Glucose Transporter mRNA.
- Published in:
- Journal of Neurochemistry, 1996, v. 66, n. 2, p. 449, doi. 10.1046/j.1471-4159.1996.66020449.x
- By:
- Publication type:
- Article
Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I.
- Published in:
- BioDrugs, 2018, v. 32, n. 2, p. 169, doi. 10.1007/s40259-018-0264-7
- By:
- Publication type:
- Article
Imaging Endogenous Gene Expression in Brain Cancer In Vivo with <sup>111</sup>In-Peptide Nucleic Acid Antisense Radiopharmaceuticals and Brain Drug-Targeting Technology.
- Published in:
- Journal of Nuclear Medicine, 2004, v. 45, n. 10, p. 1766
- By:
- Publication type:
- Article
Imaging Gene Expression in the Brain In Vivo in a Transgenic Mouse Model of Huntington's Disease with an Antisense Radiopharmaceutical and Drug-Targeting Technology.
- Published in:
- Journal of Nuclear Medicine, 2002, v. 43, n. 7, p. 948
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- Publication type:
- Article