We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Voxel-Wise Comparison of Co-Registered Quantitative CT and Hyperpolarised Gas Diffusion-Weighted MRI Measurements in IPF.
- Authors
Chan, Ho-Fung; Weatherley, Nicholas D.; Biancardi, Alberto M.; Johns, Christopher S.; Tahir, Bilal A.; Karwoski, Ronald A.; Bartholmai, Brian J.; Bianchi, Stephen M.; Wild, Jim M.
- Abstract
The patterns of idiopathic pulmonary fibrosis (IPF) lung disease that directly correspond to elevated hyperpolarised gas diffusion-weighted (DW) MRI metrics are currently unknown. This study aims to develop a spatial co-registration framework for a voxel-wise comparison of hyperpolarised gas DW-MRI and CALIPER quantitative CT patterns. Sixteen IPF patients underwent 3He DW-MRI and CT at baseline, and eleven patients had a 1-year follow-up DW-MRI. Six healthy volunteers underwent 129Xe DW-MRI at baseline only. Moreover, 3He DW-MRI was indirectly co-registered to CT via spatially aligned 3He ventilation and structural 1H MRI. A voxel-wise comparison of the overlapping 3He apparent diffusion coefficient (ADC) and mean acinar dimension (LmD) maps with CALIPER CT patterns was performed at baseline and after 1 year. The abnormal lung percentage classified with the LmD value, based on a healthy volunteer 129Xe LmD, and CALIPER was compared with a Bland–Altman analysis. The largest DW-MRI metrics were found in the regions classified as honeycombing, and longitudinal DW-MRI changes were observed in the baseline-classified reticular changes and ground-glass opacities regions. A mean bias of −15.3% (95% interval −56.8% to 26.2%) towards CALIPER was observed for the abnormal lung percentage. This suggests DW-MRI may detect microstructural changes in areas of the lung that are determined visibly and quantitatively normal by CT.
- Subjects
IDIOPATHIC pulmonary fibrosis; MAGNETIC resonance imaging; LUNG diseases; DIFFUSION coefficients
- Publication
Diagnostics (2075-4418), 2023, Vol 13, Issue 23, p3497
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics13233497