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- Title
Diarrheal Morbidity During Hematopoietic Cell Transplantation: The Diagnostic Yield of Stool Cultures.
- Authors
Berger, Tamar; Giladi, Odil; Yahav, Dafna; Ben-Zvi, Haim; Pasvolsky, Oren; Shargian-Alon, Liat; Wolach, Ofir; Rozovski, Uri; Raanani, Pia; Yeshurun, Moshe
- Abstract
Introduction: Diarrhea affects a significant proportion of patients undergoing hematopoietic cell transplantation (HCT). We explored the diagnostic yield of stool cultures for enteric pathogens among patients undergoing HCT. Methods: This is a single-center, retrospective study. Between 5/2007 and 4/2020, consecutive patients who underwent HCT were included if inpatient bacterial stool cultures were collected. Patient characteristics, results, and timing of stool cultures obtained during hospitalization were collected. Results: A total of 1072 individuals underwent autologous (n = 603) and allogeneic (n = 469) HCT. Overall, 947 stool culture samples were obtained from 561 (52%) patients with diarrheal illness during hospitalization for HCT. Most (99%) samples were obtained beyond 3 days of admission, mainly (77%) during neutropenia. Overall, only four (0.42%) (autologous, n = 3; allogeneic, n = 1) patients had a positive stool culture and in all cases Campylobacter spp. were the pathogens identified. The number of stool cultures needed-to-test to diagnose one case of bacterial infection was 237. The cost of diagnosing one case of bacterial diarrhea was US $8770. Patients with a positive stool culture did not have discerning characteristics. Conclusions: In our experience, the yield of stool cultures for enteropathogens in patients undergoing HCT is extremely low and thus should be avoided in most cases.
- Subjects
HEMATOPOIETIC stem cell transplantation; BACTERIAL cultures; BACTERIAL diseases
- Publication
Infectious Diseases & Therapy, 2021, Vol 10, Issue 2, p1023
- ISSN
2193-8229
- Publication type
Article
- DOI
10.1007/s40121-021-00415-9