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- Title
Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat.
- Authors
Arbabi-Kalati, Fateme; Mesgari-Abbasi, Mehran; Nasirinasab, Mojgan; Sohrabi, Maryam; Roshangar, Leila; Soleimani, PJafar; Khaki, Amir A.; Doustar, Yousof; JavadzadeP, Yousof
- Abstract
Background: Cyclo-oxygenase-2 5T(COX-2) 5Tspecific inhibitors were examined for predication or treatment of different tumors and it is indicated that COX-2 specific inhibitors play an important regulatory role in apoptosis of tumoral tissues. Therefore, the present study was designed in order to examine the preventive effects of a COX-2 specific inhibitor called celecoxib on 5T4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma on rat5T. Materials and Methods: In this experimental study, 30 Sprague Dawley rats (with the age of 3- 3.5 months) were selected and divided into three groups. In order to induce lingual carcinoma, 4NQO powder was prepared 3 times a week for each cage. In this study, celecoxib power was mixed with a basic food (basal diet) in order to examine the systematic effect. Tongue samples were sent to laboratory for immunohistochemical (IHC) staining and histological examination. Results: Based on morphological criteria and the ratio of apoptosis to cell proliferation, the prevalence of tongue precancerous lesions was reduced significantly by celecoxib. Conclusion: Celecoxib systematic has inhibitory effects on the 5T4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma of tongue. The effect of celecoxib is probably via suppression of cell proliferation and induction of apoptosis.
- Subjects
TONGUE cancer; CELECOXIB; CANCER chemotherapy; NITROQUINOLINE oxide; SQUAMOUS cell carcinoma; CHEMOPREVENTION; LABORATORY rats; CANCER treatment
- Publication
Zahedan Journal of Research in Medical Sciences, 2013, Vol 15, Issue 1, p1
- ISSN
2008-7977
- Publication type
Article