We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Microtubule dependent sorting of actin-binding proteins in mitosis.
- Authors
Prassler, Jana; Ecke, Mary; Gerisch, Günther
- Abstract
The patterns of Formin B and of the Arp2/3 complex formed during mitosis were studied in a mutant of Dictyostelium discoideum that produces multinucleate cells, which divide by the ingression of unilateral cleavage furrows. During cytokinesis the cells of this mutant remain spread on a glass surface where they generate a planar pattern based on the sorting-out of actin-binding proteins. During anaphase, Formin B and Arp2/3 became localized to the regions of microtubule asters around the centrosomes; Formin B in particular in the form of round, quite uniformly covered areas. These areas have been shown to be depleted of myosin II and the actin-filament crosslinker cortexillin, and to be avoided by cleavage furrows on their path into the cell.
- Subjects
MICROFILAMENT proteins; MITOSIS; MICROTUBULES; DICTYOSTELIUM discoideum; CYTOKINESIS; TUBULINS
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-61967-7