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- Title
Novel Antimicrobial Compounds as Ophiobolin-Type Sesterterpenes and Pimarane-Type Diterpene From Bipolaris Species TJ403-B1.
- Authors
Shen, Ling; Liu, Mengting; He, Yan; Al Anbari, Weaam Hasan; Li, Huaqiang; Lin, Shuang; Chai, Chenwei; Wang, Jianping; Hu, Zhengxi; Zhang, Yonghui
- Abstract
Six previously undescribed ophiobolin-type sesterterpenes, namely, bipolatoxins A–F (1 – 6); and one previously undescribed pimarane-type diterpene, namely, 1β-hydroxy momilactone A (7); together with three known compounds, namely, 25-hydroxyophiobolin I (8), ophiobolin I (9), and ophiobolin A lactone (10); were isolated and identified from the endophytic fungus Bipolaris species TJ403-B1. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic analyses (including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy data), single-crystal X-ray diffraction analyses, and comparison of experimental circular dichroism data. All compounds (except for 5) were evaluated for antimicrobial potential, which indicated that bipolatoxin D (4) showed significant inhibitory activity against Enterococcus faecalis with a minimum inhibitory concentration (MIC) value of 8 μg/mL, and ophiobolin A lactone (10) showed significant inhibitory activity against Acinetobacter baumannii and E. faecalis with MIC values of 8 and 8 μg/mL, respectively.
- Subjects
ELECTROSPRAY ionization mass spectrometry; NUCLEAR magnetic resonance; MASS spectrometry; ACINETOBACTER baumannii; ENTEROCOCCUS faecalis; CIRCULAR dichroism; LINEZOLID
- Publication
Frontiers in Microbiology, 2020, Vol 11, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2020.00856