We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acute Promyelocytic Leukemia in aWoman with Thalassemia Intermedia: Case Report and Review of Literature on Hematological Malignancies in β-Thalassemia Patients.
- Authors
Pellegrino, Claudio; Dragonetti, Giulia; Chiusolo, Patrizia; Rossi, Monica; Orlando, Nicoletta; Teofili, Luciana
- Abstract
Patients affected by transfusion-dependent β-thalassemia are prone to developing several clinical complications, mostly related to the iron overload. We report the case of a patient affected by transfusion-dependent β-thalassemia (TDT) developing acute promyelocytic leukemia (APL). In our case, the therapeutic management was significantly complicated not only by myocardial dysfunction, but also by the occurrence of the differentiation syndrome following all-trans retinoic acid (ATRA) administration. We carried out a careful revision of the current literature on the occurrence of hematological malignancies in β-thalassemia patients to investigate the major complications so far described. APL occurrence in β-thalassemia patients has been very rarely reported, and our experience suggests that TDT patients suffering pre-existing comorbidities may develop a potentially fatal complication during ATRA therapy.
- Subjects
ACUTE promyelocytic leukemia; BETA-Thalassemia; HEMATOLOGIC malignancies; LITERATURE reviews; IRON overload; BLOOD transfusion reaction
- Publication
Hematology Reports, 2022, Vol 14, Issue 4, p310
- ISSN
2038-8322
- Publication type
Article
- DOI
10.3390/hematolrep14040045