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- Title
Reposición restrictiva de calcio en pacientes con shock séptico: estudio de intervención antes-después.
- Authors
Ryoung-Eun Ko; Daun Jeong; Sumin Baek; Chi Ryang Chung; Gee Young Suh; Joonghyun Ahn; Jinseo Kim; Sung Yeon Hwang; Gun Tak Lee; Jong Eun Park; Tae Gun Shin; You Hwan Jo
- Abstract
Purpose. To study the impact of a restrictive calcium replacement protocol in comparison with a liberal one in patients with septic shock. Methods. Multicenter retrospective before-after study that estimated the impact of implementing a restrictive calcium replacement protocol in patients with septic shock. Patients admitted to an intensive care unit between May 2019 and April 2021 were assigned to liberal calcium replacement, and those admitted between May 2021 and April 2022 were assigned to a restrictive protocol. The primary outcome measure was 28-day mortality. Patients were matched with propensity scores. Results. A total of 644 patients were included; liberal replacement was used in 453 patients and the restrictive replacement in 191. We paired 553 patients according to propensity scores, 386 in the liberal group and 167 in the restrictive group. Mortality did not differ significantly between the groups at 28 days (35.3% vs 32.3%, respectively; hazard ratio, 0.97; 95% CI, 0.72-1.29) or after resolution of septic shock (81.5% vs 83.8%; hazard ratio, 0.89; 95% CI, 0.73-1.09). Nor did scores on the Sepsis-related Organ Failure Assessment scale differ (2.1 vs 2.6; P = 0.20). Conclusions. The implementation of a restrictive calcium replacement protocol in patients with septic shock was not associated with a decrease in 28-day mortality in comparison with use of a liberal protocol. However, we were able to reduce calcium replacement without adverse effects.
- Subjects
MEDICAL protocols; HOSPITAL care; PROBABILITY theory; QUESTIONNAIRES; DIETARY calcium; TREATMENT effectiveness; RETROSPECTIVE studies; SEVERITY of illness index; HOSPITAL mortality; DESCRIPTIVE statistics; SEPTIC shock; CALCIUM; EXPERIMENTAL design; CONTROL groups; HYPOCALCEMIA; ODDS ratio; RESEARCH; INTENSIVE care units; COMPARATIVE studies; CONFIDENCE intervals
- Publication
Emergencias, 2024, Vol 36, Issue 3, p204
- ISSN
1137-6821
- Publication type
Article
- DOI
10.55633/s3me/021.2024