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- Title
The efficacy of omeprazole twice daily with supplemental H<sub>2</sub> blockade at bedtime in the suppression of nocturnal oesophageal and gastric acidity.
- Authors
Orr, W. C.; Harnish, M. J.
- Abstract
Summary Background: It has been presumed that nocturnal acid breakthrough may pose a risk for the development of nocturnal gastro-oesophageal reflux. Aim: To investigate the occurrence of gastro-oesophageal reflux and acid breakthrough during polygraphically monitored sleep under conditions of powerful acid suppression with omeprazole 20 mg b.d. and an additional dose of ranitidine at bedtime. Methods: Nineteen individuals with symptomatic gastro-oesophageal reflux disease were studied. Each individual was studied on two occasions subsequent to 1 week of 20 mg of omeprazole treatment b.d. Subjects underwent 24-h oesophageal and gastric pH recording, with polysomnographic monitoring. Participants received either 150 mg ranitidine at bedtime or placebo, prior to a provocative meal. Results: Ranitidine administration resulted in a significant (P < 0.01) reduction in the percentage of time the intragastric pH < 4.0. There was no significant difference with regard to measures of gastro-oesophageal reflux, and reflux events were not noted to occur with a significantly greater frequency during periods of nocturnal acid breakthrough compared with control intervals without acid breakthrough. Conclusions: The administration of 150 mg ranitidine at bedtime did not significantly alter the occurrence of sleep-related gastro-oesophageal reflux.
- Subjects
OMEPRAZOLE; ANTACIDS; GASTROESOPHAGEAL reflux; RANITIDINE
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 17, Issue 12, p1553
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2003.01594.x