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- Title
Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical inflammation and asymmetric dimethyl-arginine levels in hypertensives.
- Authors
Thomopoulos, C.; Tsioufis, C.; Dimitriadis, K.; Tsiachris, D.; Tousoulis, D.; Manolis, A.; Alchanatis, M.; Kallikazaros, I.; Stefanadis, C.
- Abstract
In a cross-sectional study of middle aged hypertensives, those with obstructive sleep apnoea syndrome (OSAS) compared with those without OSAS, demonstrated increased levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), interleukin 18 (IL-18), tumour necrosis factor alpha (TNF-a) and asymmetric dimethyl-arginine (ADMA), at the same level of ambulatory pulsatile load and body size. Association of apnoea severity indices with the above-mentioned markers supports the incremental effect of OSAS on the cardiovascular risk duet of sub-clinical inflammation and endothelial dysfunction in the setting of hypertension.
- Subjects
SLEEP apnea syndromes; ARGININE; TUMOR necrosis factors; INTERLEUKINS; HYPERTENSION; THERAPEUTICS; MEDICAL research
- Publication
Journal of Human Hypertension, 2009, Vol 23, Issue 1, p65
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/jhh.2008.101