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- Title
MicroRNAs tune cerebral cortical neurogenesis.
- Authors
Volvert, M-L; Rogister, F; Moonen, G; Malgrange, B; Nguyen, L
- Abstract
MicroRNAs (miRNAs) are non-coding RNAs that promote post-transcriptional silencing of genes involved in a wide range of developmental and pathological processes. It is estimated that most protein-coding genes harbor miRNA recognition sequences in their 3′ untranslated region and are thus putative targets. While functions of miRNAs have been extensively characterized in various tissues, their multiple contributions to cerebral cortical development are just beginning to be unveiled. This review aims to outline the evidence collected to date demonstrating a role for miRNAs in cerebral corticogenesis with a particular emphasis on pathways that control the birth and maturation of functional excitatory projection neurons.
- Subjects
TISSUE physiology; TISSUE culture; MESSENGER RNA; DEVELOPMENTAL neurobiology; GENETIC transcription
- Publication
Cell Death & Differentiation, 2012, Vol 19, Issue 10, p1573
- ISSN
1350-9047
- Publication type
Article
- DOI
10.1038/cdd.2012.96