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- Title
Nefrotoxicidad inducida por medicamentos.
- Authors
Calderón-Ospina, Carlos Alberto; Guzmán-Ramírez, Ginna Melissa; Sarmiento-Monroy, Juan Camilo; Gómez-Angulo, Danney Loreyni; Joya-Higuera, Angélica Yasmín; Ríos-Barajas, Luisa Fernanda; Romero-Soler, Jenny Paola; Rosado-Sierra, Katiana Victoria; Soler-Barrera, Jenyffer Nathalie
- Abstract
This review includes a description of the different types of drug-induced nephrotoxicity (DIN) according to histopathologic classification, generation mechanism, clinical presentation and drugs most frequently involved. For this review, a systematic search was conducted in the Index Medicus for articles published since 1999, which were selected according to their relevance. The DIN is a finding of major clinical importance due to their high frequency and potential severity, and the lack of preventive measures in many cases. The main renal impairments caused by drugs can be classified histopathologically according to altered renal function. Thus, there is the acute tubular necrosis, interstitial nephritis, glomerular injury and vascular changes that in turn include thrombotic microangiopathy, atherosclerosis and vasculitis. Finally, some commonly used drugs with high potential for nephrotoxicity are reviewed, with emphasis on recommendations for clinical use to optimize the renal safety of these products.
- Subjects
DRUG toxicity; KIDNEY diseases; CHRONIC kidney failure; HISTOPATHOLOGY; THROMBOTIC thrombocytopenic purpura; ATHEROSCLEROSIS
- Publication
Médicas UIS, 2011, Vol 24, Issue 1, p73
- ISSN
0121-0319
- Publication type
Article