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- Title
What is the impact of HLA mismatches detected by high-resolution techniques on the outcome of unrelated donor bone marrow transplantation?
- Authors
Ottinger, H. D.; Beelen, D. W.; Grosse-Wilde, H.
- Abstract
The article studies the impact of HLA mismatches detected by high-resolution techniques on the outcome of unrelated donor bone marrow transplantation. Whether a given HLA mismatch has an impact on transplant outcome or not depends upon the specific clinical context, including the conditioning regimen, stem cell source, graft versus host disease prophylaxis, graft manipulation, etc. Thus, even the best attempts to correct for a myriad of possible clinical confounders using advanced statistical techniques may result in conclusions that are erratic or erroneous.
- Subjects
HLA histocompatibility antigens; BONE marrow transplantation; GRAFT versus host disease; BONE marrow purging; HISTOCOMPATIBILITY antigens; MEDICAL research
- Publication
Bone Marrow Transplantation, 2005, Vol 35, Issue 12, p1211
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704965