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- Title
Second Primary Tumor in Patients with Gastroenteropancreatic Neuroendocrine Tumors (GEPNETs): Data From a Retrospective Observational Unicentric Study.
- Authors
Fonseca, P. J.; Álvarez, C.; Pérez, Q.; Frunza, M.; Gutierrez, E.; Ruíz, A. L.; Rodríguez, D.; Galvan, J. A.; Bernardo, C.; Vieitez, J. M.
- Abstract
Introduction: It is known that GEPNETs are associated with a high incidence of second primary tumors, especially in the context of inherited syndromes and synchronous injuries to the intestine. Aim(s): To assess the percentage of patients with GEPNETs who develop a second primary tumor with different origin and histology. Materials and methods: We present a retrospective analysis of 166 patients (mean age 65 years, 55% males and 5% with inherited syndrome) attended in our Medical Oncology Department between 2007 and 2011. The tumor types were: GENET 58% and PNET 42%. The tumor stages were: 133%, II-III 16% and IV 51%. Results: The patients with a second primary tumor were 29% and the eight patients with inherited syndrome had at least two different cancers. Synchronous cancers were found in 16% of the patients: 39% of stage I, 13% of stage II-III and 3% of stage IV. 97% of the synchronous tumors were located in the intestinal tract. Metachronous cancers were found in 13% of patients. No second primary tumor was diagnosed in patients with previous advanced neuroendocrine cancer. Conclusion: Diagnosis of synchronous intestinal tumors is more frequently in stage I GEPNET than in stage II to IV, being usually an incidental finding during surgical resection. As in other series, in this one, the incidence of second primary tumors is higher in GEPNET (27%) than that published in other carcinomas (8%) and it would he interesting to know what causes this.
- Subjects
NEUROENDOCRINE tumors; TUMORS; SURGICAL excision; PANCREATIC tumors; ENDOCRINE gland cancer; PATIENTS
- Publication
Neuroendocrinology, 2012, Vol 96, p31
- ISSN
0028-3835
- Publication type
Article